MSMEs (Micro, Small and Medium Enterprises) is one of the economic movers in Indonesia and it can survive in national economic crisis, therefore there must be a treatment to develop it. MSMEs also has role to overcome unemployment problems since it also absorb many employee. In village area, Pesantren is an institute which is rooted in society. The number of pesanten may reach 24.206 in Indonesia and therefore its potency should be developed. The study about this matter in pesantren An Naffi’iyah shows that pesantren can be improved as the educational institute for entrepreneurship for both santri and people around it. It is hope that new MSMEs will appear through pesantren so that problems on poverty and unemployment can be solved.